Abstract
Objectives: Diabetes is increasingly recognized as a serious, worldwide public health concern. By early identifying those at risk to develop diabetes and if confirmed to be at pre-diabetes stage adequate care provided for them through lifestyle interventions or even hypoglycemic medications if necessary, thus delaying or preventing their progression to diabetic status. The study aims at assessing the risk of developing type 2 diabetes mellitus (T2DM) among healthy non-diabetic Sudanese in Khartoum city. Breast cancer (BC) is the most common cancer worldwide prevalent among women with more than one million cases and is second only to lung cancer.
 Methods: The identification of the sequences based on the unique tetramers GCAC, GTCA were selected from experimental work. The16 base pair DNA regulatory sequences of which the motifs area part of containing these motif in genes implicated in cancer CAGE1 (AAGCTGTCATTA), BRCA1(GACTGAGTCAA), ABCB1(CTCTAAGTCAT), ABCB5 (GATATGTTAAAGC) and ABI1(CTTCTGGGAA) were then selected as novel putative targets in breast cancer therapy based on their selectivity on the BC oncogenes which are not found in the normal human genome 1-23 and the sex chromosomes X and Y were obtained via computational analysis.
 Results: The single copy base pairs which will be potential drug targets as anticancer drugs were finally obtained as CTGTTATGACTGAGTCAA, CAGE1 with the 17 base pairs CATAAAAGC TGTCATTA and ABCB1 TTGCCAA CTCTAAGT CAT.
 Conclusion: It is Possible that the in silico discovery of putative anti breast cancer targets of importance in the genome.
 Peer Review History: 
 Received 18 July 2020; Revised 25 September; Accepted 12 October, Available online 15 November 2020
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 Received file 
 
 Average Peer review marks at initial stage: 5.5/10
 Average Peer review marks at publication stage: 7.0/10
 Reviewer(s) detail:
 Dr. Nkechi Obiofu Ezenobi, University of Port Harcourt, Nigeria, nkechi.ezenobi@uniport.edu.ng
 Shahinga Vanji, World Academy of Medical Sciences, Iran, shahin.gavanji@khuisf.ac.ir
 Comments of reviewer(s): 
 
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Highlights
Breast cancer is the most common malignancy in women accounting for about 18% of female cancers worldwide and over half a million diagnosed each year
It originates in the cells of the breast and several genes bearing high-penetrance mutations have been implicated in inherited disposition to Breast cancer (BC) with BRCA1 and BRCA2 being the most important, BC susceptibility genes other than BRCA1 AND BRCA2 have been identified
The selected genes have been ABCB1, CAGE1 and BRCA1 have been implicated in the proliferation and development of cancer cells
Summary
Breast cancer is the most common malignancy in women accounting for about 18% of female cancers worldwide and over half a million diagnosed each year. In Nigeria, cancer cases have increased by 21% out of which 10% are BC1 It originates in the cells of the breast and several genes bearing high-penetrance mutations have been implicated in inherited disposition to BC with BRCA1 and BRCA2 being the most important, BC susceptibility genes other than BRCA1 AND BRCA2 have been identified. Estrogen receptors ERs are dependent, inducible signal transducers which act through a non classical pathway in which liganded ERs are tethered to DNA via association with other transcription factor complexes including Fos/Jun [activator protein-1 (AP-1)– responsive elements] or SP-110. They are capable of binding to palindromic DNA sequences 5′-TGAGTCA3′ as well as similar sequences 5′-TTAGTCA-3′ and 5′TGATTCA-3′12,13. These warrant the need for the development of novel therapeutic agents in the treatment of BC via identification of potential drug targets[16]
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