Abstract
Nipah Virus is a zoo tonic virus and has re-emerged again with more deadliness. NiV has infected many animals and humans worldwide and a huge loss to life has been faced. NiV contains a Fusion protein on its outer membrane which helps in the virus entry into the host cell. This fusion protein is a virulent factor and is a major anti-viral target. Many medicinal plants have been used against viral diseases, current research aims towards the potential of three daily dietary food elements that can be used as an anti-viral agent. In-silico studies are performed with 4-hyroxypanduratin A, 6-gingerol and Luteolin against the NiV-F and binding energies were calculated. It was reported that these phyto-compounds have good negative binding energies and they have the promising potential against Nipah Virus. Further in-vitro research can be performed with these phyto-compounds to design a specific drug against Nipah Virus.
Highlights
The Nipah virus belongs to the Henipavirus class concern and two distinct strains of Nipah virus of the Paramyxoviridae family and outbreaks of (NiV) have been identified based on diffusion
Fresh rhizomes are utilized to cure inflammatory disorders including dental caries, dysentery, diarrhoea, wounds, swelling, gum and tooth problems, colds and dry cough, and dermatitis and to act as a diuretic [3]. 4-hyroxypanduratin A is the main constituent of B. rotunda and it has been established in several studies that 4hyroxypanduratin A is effective against several diseases
Design: 3-dimensional structures for Nipah Fusion protein was downloaded from Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) and 3-dimensional structures for 4hyroxypanduratin A, 6-gingerol and Luteolin was downloaded from Public Chemistry (PubChem)
Summary
The Nipah virus belongs to the Henipavirus class concern and two distinct strains of Nipah virus of the Paramyxoviridae family and outbreaks of (NiV) have been identified based on diffusion. It has been reported that Fruit bats or flying foxes are the spreader and are responsible for the transmission of the virus to humans as well as animals. NiV has been found in wild bats and on fruits like date palm which is infected by the urine or saliva of these animals [2]. The rhizome of Zingiber officinale (ginger) is used as a spice and herbal medicine all over the world. It includes gingerols, a group of spicy phenolic compounds. As a result of its effectiveness and regulation of many targets, including its safety for human usage, 6-gingerol has attracted a lot of attention as a possible therapeutic agent against a variety of illnesses. This study is conducted to find the efficacy of this compound against the NiV and develop an effective anti-viral
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