Abstract
Breast cancer is the serious health concern in India causing the highest mortality rate in females, which occurs due to uncontrolled cell division and can be metastasize to other parts of the human body. Interactions with estrogen receptor (ER) alpha are mainly responsible for the malignant tumors with regulation of the transcription of various genes as a transcription factor. Most of the drugs currently used for the breast cancer treatment produce various side effects and hence we focused on natural compounds which do not exhibit any toxic effect against normal human cells. Structure of human ER was retrieved from the Protein Data Bank and the structures of flavonoid compounds have been collected from PubChem database. Molecular docking and drug likeness studies were performed for those natural compounds to evaluate and analyze the anti-breast cancer activity. Finally two compounds satisfying the Lipinski's rule of five were reported. The two compounds also exhibited highest binding affinity with human ER greater than 10.5 Kcal/mol. The results of this study can be implemented in the drug designing pipeline.
Highlights
Breast cancer is one of the most recurring worldwide diagnosed and deadliest cancers next to lung cancer with a high number of mortality rates among females (Benson and Jatoi, 2012)
Breast cancer is the serious health concern in India causing the highest mortality rate in females, which occurs due to uncontrolled cell division and can be metastasize to other parts of the human body
Most of the drugs currently used for the breast cancer treatment produce various side effects and we focused on natural compounds which do not exhibit any toxic effect against normal human cells
Summary
Breast cancer is one of the most recurring worldwide diagnosed and deadliest cancers next to lung cancer with a high number of mortality rates among females (Benson and Jatoi, 2012). Most of the drugs currently used for the breast cancer treatment produce various side effects and we focused on natural compounds which do not exhibit any toxic effect against normal human cells. Molecular docking and drug likeness studies were performed for those natural compounds to evaluate and analyze the anti-breast cancer activity.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
