In-Silico Comparison of the SARS-COV-2 Genome and Other Viruses

Roxana Apetrei

doi:10.26717/bjstr.2020.30.004958

Abstract

Andreea Lorena Mateescu1, NicolaeBogdan Mincu1,2, Marioara Avram1,3, Roxana Apetrei1,2* and Dana Stan1 Author Affiliations 1DDS Diagnostic,032032 Bucharest, Romania 2Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, Romania 3National Institute for Research and Development in Microtechnologies (IMT), Romania Received: September 08, 2020 | Published: September 16, 2020 Corresponding author: Roxana Apetrei, Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, 060101 Bucharest, DDS Diagnostic, 032032 Bucharest, Romania DOI: 10.26717/BJSTR.2020.30.004958

Highlights

Taking these ideas step by step we decided to investigate the SARS-COV-2 genome and some specific proteins in order to determine if notable similarities can be found between this virus and other animal specific Coronaviruses and viruses such as: human Alphacoronavirus, Middle East respiratory syndrome coronavirus (MERS), Hepatitis C virus genotype 1, Ebola virus, Rabies virus and Severe acute respiratory syndrome virus (SARS)
We started looking at animal specific coronaviruses and we first evaluated the homology between bat and pangolin coronaviruses and the human one and both showed highly similar sequences, with percentages such as 70,56% for the bat isolate and 91,64% for the pangolin isolate (Figure 7)
Our study revealed that SARS and SARS-COV-2 spike proteins sequences have a similarity of 78,38%, pangolin spike protein had

Summary

Introduction

We started looking at animal specific coronaviruses and we first evaluated the homology between bat and pangolin coronaviruses and the human one and both showed highly similar sequences, with percentages such as 70,56% for the bat isolate and 91,64% for the pangolin isolate (Figure 7). Taking these ideas step by step we decided to investigate the SARS-COV-2 genome and some specific proteins in order to determine if notable similarities can be found between this virus and other animal specific Coronaviruses and viruses such as: human Alphacoronavirus, Middle East respiratory syndrome coronavirus (MERS), Hepatitis C virus genotype 1, Ebola virus, Rabies virus and Severe acute respiratory syndrome virus (SARS).

Results

Conclusion