Abstract
Heterologous production of terpenoids from plants which are of medicinal and industrial interests is getting much attention. For this purpose saccharomyces cerevisiae is the most commonly used host but the yield of terpenoids is much lower. The main aim of this review is to study the terpenoid pathways of saccharomyces cerevisiae, effect of respective host metabolism as well as to study the effect of different carbon sources in silico by means of elementary mode analysis. The production and yield of IPP was main focus point in order to find out the novel metabolic engineering strategy for increasing production of terpenoids. With glucose acting as a substrate, MVA pathway has low potential to produce terpenoids as compared to DXP pathway if we consider formation of precursor. Moreover the carbon source also has impact on yield with nonfermentable source providing more biomass. At last several knock out methodologies were being employed which identified minimal cuts sets for enhanced growth of terpenoids.
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