In-silico analysis of Lysenin as potential anti-cancer agents targeting sphingomyelin in colon cancer

Abstract

Colorectal cancer is a malignant neoplasm disease and is defined as a malignancy that occurs in the large intestine. In the world colon cancer ranks fourth meanwhile in Indonesia, colon cancer placed in the third rank after another cancer. The aim of this study is to find alternative way to help chemotherapy agent that already exist which is 5-FU for cure colon cancer. As already know 5-FU still lack of weakness so in this study hope that the sample that test in this study which is lysenin can be co-chemotherapy agent for colon cancer. Lysenin from coelomic fluid earth worm Lumbricus rubellus will bind with ligand sphingomyelin with docking method where the result will be new binding complex. After that the new complex will be test with hnRNP M4 membrane complex on colon cancer with docking method too and will see whether there’s binding affinity between lysenin sphingomyelin binding complexes with hnRNP M4.