Abstract
AbstractCardiovascular disease is the major cause of disability and premature death throughout the world and contributes substantially to the escalating costs of health care. Insulin like growth factor binding protein 4 (IGFBP-4) mainly belongs to the family of IGFB protein. Over expression of IGFBP-4 leads to cardiovascular diseases namely stroke, acute myocardial infarction and heart failure. IGFBP-4 serves as an effective drug target against cardiovascular disease. Hence, ligand based virtual screening was persuaded in the present study to propose potential inhibitors of IGFBP-4. Two inhibitors (mainly from literature search) were selected to initiate high throughput virtual screening from small molecule databases namely, NCI, ChemBank, ChemPDB, AKos GmbH, Asinex Ltd and KEGG ligand. The structures listed through database search were docked with IGFBP-4 using virtual screening workflow of Maestro v9.2. Three leads that showed better binding affinity and good correlation with two published inhibitors were proposed as potential IGFBP-4 inhibitors. The three proposed leads showed good pharmacological properties in comparison to the two existing inhibitors. The analyses supported efficiency of three leads for next generation drug designing for cardiovascular diseases.
Highlights
Cancer is a class of diseases characterized by uncontrolled cell growth in which cells undergo alterations of their normal functions that progressively lead to the genesis of a tumor
Neutrophil-gelatinase associated lipocalin(NGAL) was generally found in activated human neutrophils but it is expressed in human tissues kidney, prostate and epithelia of the respiratory and alimentary tracts
Neutrophil gelatinase–associated lipocalin (NGAL) a 25 kDa glycoprotein covalently bound with matrix metalloproteinase-9(MMP-9) in human neutrophils
Summary
Cancer is a class of diseases characterized by uncontrolled cell growth in which cells undergo alterations of their normal functions that progressively lead to the genesis of a tumor. Neutrophil-gelatinase associated lipocalin(NGAL) was generally found in activated human neutrophils but it is expressed in human tissues kidney, prostate and epithelia of the respiratory and alimentary tracts
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
