In Silco Molecular Modeling of Chalcone Based Aryloxyethylamines as Antihyperglycemic Agents

Abstract

Despite enormous efforts have been made in the search for new drugs, diabetes mellitus (DM) still remains the cause of mortality worldwide. A series of chalcone based aryloxyethylamines were synthesized and evaluated for their anti-hyperglycemic activity in SLM and STZ rat models. The majority of the compounds exhibited temperate to good activity ranging from 18.0% to 39.8% in SLM and 14.6% to 31.5% in STZ models, respectively. The most potent compound 31 exhibited glucose lowering of 27.0% in SLM and 31.5% in STZ models. A definite structure–activity relationship was observed while varying the nature and position of the different amines in ring-A of chalcone.