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Abstract
We thank Dr Schultheiss for his interest in our publication,1 his valuable insights, and for highlighting the excellent didactic paper by Dr David F. Herring2 that provided the pioneering foundations for use of statistical approaches, including maximum likelihood and testing the fit in dose response modeling. Our paper aimed to demonstrate in a practical step-by-step manner the full process of building a dose response model starting with data-driven approaches and describing potential pitfalls for practitioners and newbies to the field.
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