Abstract
We do agree with Dr. Beam that neurologic sequelae after bacterial meningitis are related to several factors other than antibiotic treatment. However, we do not feel that observations of clinical outcome related to antibiotic treatment are quite irrelevant. Little is known about interaction between antibiotics during clinical conditions. Also a slight antagonism between ampicillin and chloramphenicol could result in delayed CSF sterilization, for which hearing loss ought to be a sensitive indicator. The overrepresentation of sequelae in the group treated with ampicillin and chloramphenicol concomitantly was in fact to a great extent due to hearing loss, while other residuals were found in about equal frequency in all treatment groups.
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