In reply: Oral erythema multiforme: trends and clinical findings of a large retrospective: European case series

Abstract

The authors are very appreciative of comments presented by Professor Brown regarding our recent publication,1Celentano A. Tovaru S. Yap T. Adamo D. Aria M. Mignogna M.D. Oral erythema multiforme: trends and clinical findings of a large retrospective European case series.Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120: 707-716Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar which highlighted the applicability of diagnostic criteria proposed by several authors in the last two decades.2Williams P.M. Conklin R.J. Erythema multiforme: a review and contrast from Stevens-Johnson syndrome/toxic epidermal necrolysis.Dent Clin North Am. 2005; 49: 67-76Abstract Full Text Full Text PDF PubMed Scopus (56) Google Scholar, 3Bastuji-Garin S. Rzany B. Stern R.S. Shear N.H. Naldi L. Roujeau J.C. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme.Arch Dermatol. 1993; 129: 92-96Crossref PubMed Scopus (1312) Google Scholar, 4Assier H. Bastuji-Garin S. Revus J. Roujeau J.C. Erythema multiforme with mucous membrane involvement and Stevens-Johnson syndrome are different disorders with distinct causes.Arch Dermatol. 1995; 131: 539-543Crossref PubMed Scopus (273) Google Scholar, 5Auquier-Dunant A. Mockenhaupt M. Naldi L. Correia O. Schroder W. Roujeau J.C. Correlations between clinical patterns and causes of erythema multiforme major, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Results of an international prospective study.Arch Dermatol. 2002; 138: 1019-1024Crossref PubMed Google Scholar, 6Cote B. Wechsler J. Bastuji-Garin Assier H. Revuz J. Roujeau J.-C. Clinicopathologic correlation in erythema multiforme and Stevens-Johnson syndrome.Arch Dermatol. 1995; 131: 1268-1272Crossref PubMed Scopus (87) Google Scholar, 7Ayangco L. Rogers III, R.S. Oral manifestations of erythema multiforme.Dermatol Clin. 2003; 21: 195-205Abstract Full Text Full Text PDF PubMed Scopus (131) Google Scholar We agree that future studies should consider the use of these presently well-established diagnostic criteria differentiating between erythema multiforme minor (EMm), erythema multiforme major (EMM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). This may allow the clinical community to achieve more accurate epidemiologic data that can contribute to a better understanding and management of the disease. Oral erythema multiforme: trends and clinical findings of a large retrospective: European case seriesOral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyVol. 121Issue 6PreviewCelentano et al.1 are to be congratulated on their recent publication. This excellent addition to the literature reports a retrospective case series of 60 oral erythema multiforme (EM) patients. However, presently, diagnostic criteria that distinguish between EM major (EMM), EM minor (EMm), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are available. Celentano et al.1 have combined all of these diagnostic entities within the category of EM. This grouping is certainly appropriate, since the study patient population was initiated in 1982, when all such diagnoses would have been described within the category of EM. Full-Text PDF