Abstract
We appreciate the observation reported by Cheung et al, and agree with their findings. We reported similar results on survival in premature infants with pulmonary interstitial emphysema in 1986. These data show that high-frequency oscillatory ventilation (HFOV) response delineates two groups of infants with different outcomes. It is important to note that most neonates treated with HFOV have improved ventilation, but that a smaller proportion of neonates have improved oxygenation. In our experience improved oxygenation is a better predictor of outcome than improved ventilation.
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