In pediatric patients who have penicillin skin testing with minor determinants, an oral challenge isn't needed

Abstract

Penicillin skin testing (PST) and oral drug challenges are two methods to prove penicillin tolerance. The current standard is PST with Pre-Pen (benzylpenicilloyl polylysine) and Penicillin G followed by direct oral challenge with amoxicillin. We hypothesized that in the pediatric population oral drug challenge is not needed following PST if minor determinant mixtures are included in PST.