Abstract
Objective: Non-steroid anti-inflammatory drugs can change serum thyroid hormone concentrations by binding to serum proteins. If misunderstood, this situation can give way to inappropriate diagnoses and faulty treatment planning for thyroid diseases in clinical practice. The purpose of our study was to investigate the effects of ketoprofen, lornoxicam, and etofenamate, which are frequently used in clinical practice, on thyroid function tests. Methodology: The study covered 28 rabbits divided into 4 groups. Groups were administered intramuscular injections daily for 10 days. Thyroid hormones concentrations were tested in the blood samples end of day 10. Results: An increase in free thyroxin level in the lornoxicam group was recorded on day 7 in comparison to other groups (p=0.015). There was a statistical decrease regarding thyroid stimulant hormone concentration after day 5 in all three groups (Day 5 p=0.000, day 7 p=0.003, day 10 p=0.00). Conclusion: We believe that previous history of non-steroid anti-inflammatory drug use should be taken into consideration within the scope of patients’ anamneses because non-steroid anti-inflammatory drug use can change the results of thyroid function tests and this change may lead to misevaluations and mistreatment not only for patients with thyroid diseases but also for normal patients.
Highlights
Many drugs affect the results of thyroid function tests
We believe that previous history of non-steroid anti-inflammatory drug use should be taken into consideration within the scope of patients’ anamneses because non-steroid anti-inflammatory drug use can change the results of thyroid function tests and this change may lead to misevaluations and mistreatment for patients with thyroid diseases and for normal patients
The purpose of this study is to investigate the effects of three Non-Steroidal Anti-Inflammatory Drugs (NSAID), which are being frequently used in daily practice and frequently prescribed, on rabbits’ thyroid function tests
Summary
Many drugs affect the results of thyroid function tests. There are many target areas for the interaction of drugs in thyroid hormone synthesis, transport, metabolism, and absorption. A very small portion of thyroid hormones (about T3=0.3%; T4=0.03%) are found free in the circulation and carry out biological activities. Non-Steroidal Anti-Inflammatory Drugs (NSAID) especially affects the binding areas of thyroid hormones’ serum proteins and temporarily increases serum thyroid hormone levels. This, in turn, suppresses serum thyroid stimulant hormone (TSH) levels [1,2]. If this condition is misunderstood, the changes that are brought about by drugs can lead to inappropriate diagnosis and faulty treatment planning
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