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Abstract
In memoriam: Kuan-Teh Jeang, MD PhD (1958–2013)
Highlights
Talking about the golden era of the National Institutes of Health (NIH), Nobel laureates Joseph Goldstein and Michael Brown concluded in a recent issue of Science that "ambitious young physicians juxtaposed to cuttingedge basic scientists can themselves make fundamental discoveries" [1]
Research on HTLV-1 that causes adult T-cell leukemia was another area close to Teh’s heart. He started his work on HTLV-1 when he was with George Khoury
Over the years he laid a number of cornerstones that shaped the field. His studies provided molecular details of the activation of viral and cellular transcription by HTLV-1 oncoprotein Tax mediated through CREB and NF-κB, and derived mechanistic insights into Taxinduced oncogenic transformation of T lymphocytes
Summary
Talking about the golden era of the National Institutes of Health (NIH), Nobel laureates Joseph Goldstein and Michael Brown concluded in a recent issue of Science that "ambitious young physicians juxtaposed to cuttingedge basic scientists can themselves make fundamental discoveries" [1]. Teh had been working at the NIH for 27 years and was chief of the Molecular Virology Section in the Laboratory of Molecular Microbiology of the National Institute of Allergy and Infectious Diseases. He led a highly productive group and published more than 250 scientific papers in the broad field of biomedical science, with a focus on two human retroviruses: human immunodeficiency virus type 1 (HIV-1) and human T-cell His findings revealed new clues to fundamental questions such as how HIV-1 transcribes its RNA and how HTLV1 transforms cells.
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