Abstract
The present study offers a novel approach that may explain the mechanisms of pathogenicity of the auto immune destructive disorder, Lupus Erythematosus. It is proposed that deposition of immune complexes and complement components in tissue is mediated by highly cationic histones released from neutrophils nets the phenomenon of netosis. Histones act a potent opsonic factor similar to antibodies which interact by strong electrostatic forces with negatively-charged domains in immune complexes and complements facilitating their deposition and also their internalization by hosts’ cells. However, the main cause of cell and tissue damage in Lupus is inflicted by the plethora of toxic pro inflammatory agonists released by neutrophils and by macrophages recruited to inflamed tissues by cytokines. The melioration of tissue damage may be initiated by highly anionic heparins, which neutralizes histones’ action if also combined with steroids, colchicin and methtorxate as well as by other agents which retard leukocytes migration and functions.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of still an unknown cause that can affect virtually any organ of the body
The present study offers a novel approach that may explain the mechanisms of pathogenicity of the auto immune destructive disorder, Lupus Erythematosus
3) Cationic Histone from PMMs nets may function as potent opsonic agents which possess properties similar to antibodies, may interact with and bind by strong electrostatic forces to negatively-charged domains in immune complexes and complement components, facilitating their binding, deposition and possibly their internalization by tissue cells
Summary
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of still an unknown cause that can affect virtually any organ of the body. Lupus can affect men and women of any race or age. Specific areas of the body that may be affected during the course of SLE include: the skin, joints, muscles and kidneys. The blood may be affected during the course of lupus, resulting in low red blood cell count, low white blood cell count and low platelet counts. Patients show variable clinical features ranging from mild joint and skin involvement to life-threatening renal, hematologic, or central nervous system involvements. The exact causes of systemic SLE still remain unclear, genetic, hormonal, and environmental factors may contribute to the development of the disease [1]. No reasonable explanations have been offered to explain the mechanisms by which immune complexes and complement components are deposited in tissues and how this process can be prevented
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
