Abstract
BackgroundWe aimed to assess whether the levels of FFAs (free fatty acids) in ACS (acute coronary syndrome) patients depend on the extent of myocardial ischemia during the subacute phase of ACS attack.MethodsA total of 892 consecutive CAD (coronary artery disease) subjects undergoing coronary angiography were enrolled. The FFAs contents were measured based on enzymatic assay. The relationship between FFAs and Gensini score and ACS susceptibility was assessed.ResultsIn the overall population, the upper FFAs quartile was accompanied with higher ischemia parameters and increased occurrence of ACS and STEMI (ST-segment elevation myocardial infarction) (P < 0.05). The FFAs concentrations were approximately 1.5-fold higher in ACS than in stable CAD patients, roughly 1.3-fold higher in STEMI than non-STEMI ACS patients and probably 1.3-fold higher in non-STEMI ACS than in stable CAD patients. After adjusted for traditional cardiovascular risk factors, the FFAs level remained a risk factor for a higher Gensini score with more than 40 (P < 0.001) and prevalent ACS (P < 0.001). After adjusted for traditional risk factors, FFAs levels after natural logarithm transformation were associated with hs-CRP and WBC counts in ACS patients. A multiplicative interaction was found between hs-CRP, WBC counts and FFAs in incident ACS and higher Gensini score (P < 0.001).ConclusionsHigher in-hospital levels of FFAs persist and may reflect the severity of ischemia and necrosis during the subacute phase of ACS attack.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-016-0199-1) contains supplementary material, which is available to authorized users.
Highlights
We aimed to assess whether the levels of free fatty acids (FFAs) in acute coronary syndrome (ACS) patients depend on the extent of myocardial ischemia during the subacute phase of ACS attack
Clinical characteristic The study population consisted of 404 stable coronary artery disease (SCAD) patients, including 294 chronic stable angina patients,110 old myocardial infarction patients and 488 ACS patients, including 108 Unstable angina (UA) patients, 191 NSTEMI patients and 189 ST-segment elevation myocardial infarction (STEMI) (ST segment elevation myocardial infarction) patients
The distribution of FFAs quartiles were slightly unbalanced with traditional cardiovascular risk factors such as age, smoking, fasting blood glucose, high-sensitivity C-reactive protein (hs-CRP) and the atherogenic lipid parameters including total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), TG (P < 0.05)
Summary
We aimed to assess whether the levels of FFAs (free fatty acids) in ACS (acute coronary syndrome) patients depend on the extent of myocardial ischemia during the subacute phase of ACS attack. Plasma free fatty acids (FFAs) levels are elevated within 12 h after the onset of acute myocardial infarction (AMI) [1], elevated FFAs are associated with worse outcomes including increased risk of arrhythmia [2], sudden cardiac death and total mortality [3]. Our previous study found that plasma FFA compositions were dysregulated in CAD (coronary artery disease) patients, partly influenced by age and gene polymorphisms [9, 10]. Ma et al BMC Cardiovascular Disorders (2016) 16:29 ischemia of ACS during subacute phase, and further 3-vessel disease, defined as stenosis of more than 50 % of investigated whether this was influenced by hs-CRP
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
