Abstract
EVIDENCE-BASED ANSWER Vitamin C does not reduce incidence of the common cold in the general population, but appears to have a protective effect in strenuous athletes (SOR: A, metaanalysis of RCTs). Daily dosing of vitamin D, but not bolus dosing, reduces respiratory tract infections (RTIs) in the general population (SOR: B, meta-analysis of heterogeneous RCTs). Neither multivitamin nor vitamin E supplementation reduces the incidence of RTI in healthy older adults (SOR: B, single RCT).
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