Abstract
Selectively modified silica materials with uniform hexagonally ordered cylindrical mesopores were synthesized by combination of sol‑gel condensation and postsynthetic chemical modification. Hexagonally arranged porous structure of silica carriers was confirmed by X-ray diffraction and low‑temperature ad‑desorption of nitrogen. Content of functional groups immobilized onto external surface of silica particles was determined from chemical analysis of surface reaction products. Release capability of MCM‑41 mesoporous silicas selectively modified with N‑(2‑aminoethyl)‑3‑aminopropyl or N‑[N’-(N’-phenyl)-2-aminophenyl]‑3‑aminopropyl groups was studied by use of para‑aminobenzoic acid as model biologically active substance. It has been found that desorption of aromatic amino acid from mesoporous channels of silica can be regulated using pH-sensitive functional groups which are chemically bounded with outer silica surface.
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