健康診査で評価した頚動脈IMTによる動脈硬化予防のためのリスクの解析

Abstract

Objective: Early identification of patients at risk of arteriosclerosis is critical, as such patients require considerable information about lifestyle modification and methods of treatment. One purpose of periodic health checkups is to prevent the development and progression of arteriosclerosis. We performed carotid artery ultrasonography at a health checkup and examined the associations between maximal progression of carotid intima-media thickness (max IMT) and risk factors for arteriosclerosis.Methods: The study comprised 1007 persons with no history of cerebrovascular disorders (602 men, mean age ± SD 53.2 ± 10.8 years ; 405 women. 53.1 ± 11.7 years) . The risk of arteriosclerosis was defined according to The Examination Committee of Criteria for Metabolic Syndrome; age and body mass index were added to each item.Results: Max IMT was positively associated with age and risk of arteriosclerosis. A max IMT over 1.1 mm was positively associated with age. systolic arterial pressure. abdominal circumference, and triglyceride level. In addition, after adjustment for age. the risk of arteriosclerosis was significantly associated with abdominal circumference (odds ratio. 1.86 ; 95% confidence interval. 1.15 to 3.00; p = 0.011) and triglyceride level (2.20,1.39 to 3.46, p = 0.001).Conclusion: Our findings indicate that reduction of abdominal circumference and triglyceride level may help limit the progression of arteriosclerosis in the carotid artery.