Abstract

Introduction: Parkinson disease (PD) is a complex disorder for which both rare and common genetic variants contribute to the pathogenesis. Genetic forms of PD may have different phenotype compared to idiopathic patients. Mutations of the gene for glucocerebrosidase (GBA) have been recognized as the major genetic risk factor for PD. Impulse control behaviours (ICBs) are among the most disabling side effects related to dopamine agonists. Aim of this study was to assess prevalence and severity of ICBs in GBA carriers of PD.

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