IMPS-32GLIOBLASTOMA MULTIFORME AFTER SEVERE WEST NILE VIRUS NEUROINVASIVE DISEASE

Abstract

OBJECTIVE: Acute West Nile Virus infection has been shown to cause a broad spectrum of neurological disorders. Beyond cognitive symptoms, little is described regarding long-term sequelae in patient that have suffered from acute West Nile neuroinvasive disease. CASE: We present a case of a patient that suffered from severe West Nile neuroinvasive disease with full recovery, however was subsequently diagnosed with glioblastoma multiforme and passed away two years later. DISCUSSION: We also note a potential mechanism in which the west nile infection may cause changes on a cellular molecular signaling level that may explain a correlation between the two disease processes. West Nile infection has been shown to result in increased expression of S100B, a glial protein biomarker with broad functions. S100B is known to increase expression of RAGE (receptor for advanced glycosylation end products), a protein documented to be in abundance in GBM tumors. CONCLUSION: To our knowledge, this is the first reported case of a patient with known history of West Nile neuroinvasive disease being subsequently diagnosed with GBM. WNV has potential for altering cellular signaling at a molecular level and increasing expression of molecules known to be in abundance in high grade glioma. Given this association, further investigations are warranted looking into the potential risk for developing CNS neoplasm, as well as further studying the potential relation between the two diseases.