Abstract
We report trends in manifestations, treatment, and outcomes of 355 children with culture-confirmed melioidosis over 10 years at a pediatric hospital in northern Cambodia. Bacteremia and presentation with pneumonia were risk factors for death. A total of 39 children recovered after being given only oral antimicrobial drug treatment.
Highlights
Antimicrobial drug therapy for melioidosis comprises 2 phases: intravenous treatment for >10 days, followed by a prolonged, oral, eradication phase for a minimum of 12 weeks [5,6]
Our study illustrates the challenges associated with providing care for children who have melioidosis at a pediatric hospital in northern Cambodia
3 care in a pediatric intensive care unit and an on-site diagnostic microbiology laboratory supported by an active clinical microbiology liaison service [10]
Summary
§A total of 9 children died within 24 h (before culture results were available), and 2 were switched directly to oral treatment. The proportion of bacteremic children remained consistent over the study period (Appendix Figure 4). Eleven children did not receive an effective intravenous drug; 9 died within 24 hours (before culture results were available), and 2 were switched directly to an oral treatment. Adjusted analyses, including only children
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