Abstract
In recent decades, probiotic products have been increasingly used to prevent certain gastro-intestinal and urogenital disorders, to improve the general condition of the body and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs in the form of capsules, powders, and solutions. Optimization of technological processes of production and packaging of these products aims to maintain probiotic characteristics while adhering to all criteria during production that ensure quality, bioavailability and optimal therapeutic effects. In this paper, the importance of choosing primary and secondary packaging materials was explored with the aim of preserving the viability of probiotic cells in capsules for two years, i.e. during the shelf life. By comparing the applications of polyvinyl chloride (PVC) and PVC/polyvinylidene chloride/polyethylene blister foils, better protection of probiotic cells was observed by applying the multilayer foil. In addition, in this research, further improvements of probiotic cell protection were achieved by applying a secondary packing-flow pack bag with inert gas for storing multilayered blisters.
Highlights
In the last several decades, probiotic products have been increasingly used for the prevention of certain gastrointestinal and urogenital disorders, to improve the general condition of the human body, and as a supplement to pharmacological therapy
The increasing use of probiotic products obliges manufacturers to carefully choose an effective probiotic strain and to optimize production parameters in order to preserve the viability of probiotic cells
The pharmaceutical production of probiotics satisfies the needs of users for a safe and effective probiotic product in a comfortable encapsulated form that can be stored at a temperature of up to 25 oC
Summary
In the last several decades, probiotic products have been increasingly used for the prevention of certain gastrointestinal and urogenital disorders, to improve the general condition of the human body, and as a supplement to pharmacological therapy. They are most often registered as dietary supplements, and less often as drugs. Probiotic products are formulated through a careful selection of strains with probiotic potential followed by strength standardization in order to produce a commercially viable product [3]. After the selection of strains, it is necessary to ensure that the therapeutic effect of probiotics is demonstrated in a daily dose of 108 to 1010 probiotic cells [4]
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