Improving the spatial resolution of a pixelated LaBr3(Ce) scintillator coupled with a multi-pixel photon counter array for boron neutron capture therapy

Abstract

Fundamental preclinical research with mice to improve boron neutron capture therapy requires a prompt gamma-ray imaging detector that can chart the real-time accumulation of 10B in tumors. This study aimed to improve the spatial resolution of our previous detector, which was based on a slab-shape LaBr3(Ce) scintillator, by changing to a pixelated 8 × 8 array scintillator.The difference between the scintillation-light detection processes, such as Compton scattering and the photoelectron effect, affects energy resolution. This was experimentally revealed and evaluated with Monte Carlo simulations. The events caused by Compton scattering were eliminated, and our detector obtained the desired energy resolution for 511 keV gamma rays at 5.0 ± 0.4 %. The spatial resolution was evaluated using collimated gamma rays and was found to be better than that of the previous system because the scintillation light did not spread over the pixelated scintillator. As a result, the proposed detection system had the energy resolution to discriminate between 478- and 511-keV gamma rays to obtain the 10B concentration. The lateral and vertical spatial resolutions FWHM of the improved system were 5.9 mm and 5.2 mm, respectively, which were better than the value of 8.0 mm provided by the previous system to visualize the two-dimensional distribution in real time.