Abstract
PurposePositive margins after gastrectomy have been associated with poor patient prognosis. This study aimed to identify risk factors associated with margin-positive resections.MethodsThe National Cancer Database was queried from 2004 to 2014 for all patients with gastric adenocarcinoma who underwent resection with curative intent and had known margin status. Univariable and multivariable logistic regression analysis was performed to identify variables associated with positive margins.ResultsA total of 32,193 patients were identified who met study inclusion criteria, of which 11.8% (3786 patients) had a margin-positive resection. Tumor size > 6 cm, T3 or T4 tumors, tumor location in the body of stomach or in multiple regions, signet ring cell histology, presence of lymphovascular invasion, positive lymph node involvement, and lack of neoadjuvant therapy were independently associated with an increased risk of positive margins.ConclusionsAdvanced disease characteristics, aggressive tumor pathology, and absence of neoadjuvant therapy were associated with margin-positive resections.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have