Abstract
Improving the performance of oral rotavirus vaccines
Highlights
Oral rotavirus vaccines have significantly improved outcomes in high-income countries, where emergency room visits and hospitalisations have decreased by over a half from the prevaccine era
The issue is more complex in low-income and middle-income countries (LMICs), with lower vaccine effectiveness and a continued predominance of rotavirus as a cause of acute diarrhoeal disease even after the vaccine introduction.[3]
In 2012, a model based mainly on WHO–UNICEF coverage surveys in 2010 and vaccine performance derived from efficacy trials and limited effectiveness data from Latin America showed that removing age restrictions for rotavirus vaccination would avert an additional 47–200 rotavirus deaths and cause an additional 294 (161–471) intussusception deaths.[6]
Summary
Oral rotavirus vaccines have significantly improved outcomes in high-income countries, where emergency room visits and hospitalisations (ie, admission to hospital) have decreased by over a half from the prevaccine era.
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