Abstract
The fixed-dose procedure and the acute-toxic-class method provide alternatives to the LD50 test for the classification of substances by their acute oral toxicity. This paper uses a general mathematical model to explore a wider class of fixed-dose procedures. In these procedures the number of animals included at each dose and the decision criteria regarding the next dose to be used are altered. The use of a number of measures of performance for the procedures, including the expected number of deaths caused and the probability that a substance is given an inappropriate classification, enable comparison of the procedures in this class.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
