Improving the Diagnosis of Rejection by Molecular Phenotype of Endomyocardial Biopsies: Single Center Insights from the Interheart Study

Abstract

Endomyocardial biopsy (EMB) is the standard of practice for diagnosis of rejection in heart transplant. However, reproducibility of EMB pathology reading (pEMB) may yield to high diagnostic variability, questioning its overall accuracy. In addition, correlation of current grading of pEMB with clinical phenotypes also is uncertain. Seeking to improve the precision in rejection diagnosis and to guide the interpretation of pEMB, we used a microarray-based analysis to identify molecular phenotypes (MP) associated with rejection.