Abstract

The Liver Cancer Study Group of Japan has been conducting a follow up study of primary liver cancer since 1965 [1-7]. The records of 38,255 patients show that primary liver cancer in Japan has the following characteristics: 1. Over 90% of all microscopically proven liver cancers are hepatocellular carcinomas 2. The incidence of primary liver cancer is highest in the sixth decade of life 3. Primary liver cancer is more common in men than in women 4. Many patients have a past history of hepatitis and frequently have hepatic cirrhosis; however, the number of carriers of HBs antigen has been decreasing (40% in 1970, 22.5% in 1987) 5. About half of the hepatocellular carcinoma patients have high blood levels of AFP

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