Abstract
In this study, we assessed the efficacy and safety of four skin care products indicated for skin hydration (Aqua Therapy® and Perfecta® ), skin aging (Unica Resurfacing Therapy® ) and sensitive skin (Comfort Therapy® ), in four groups of 7 volunteers with different skin types. These products belong to four skin care ranges (Aqua® , Perfecta® , Unica® and Comfort® ) and are formulated with a specific combination of active compounds (Dermo28® ). Evaluation of sebum secretion, hydration and pH of the skin (all groups), wrinkle severity (Unica Resurfacing Therapy® ) and erythema (Comfort Therapy® ) was performed at baseline and after 4 weeks of treatment. A significant increase in hydration was recorded in subjects with dry skin receiving Aqua Therapy® for facial hydration and Perfecta® for body hydration, respectively (p ® group. In subjects with sensitive skin (Comfort Therapy® ), a decrease in erythema (p = 0.012), an increase in sebum secretion (p = 0.001) and hydration (p < 0.001), and a reduction in pH (p = 0.005) were detected at the end of treatment. Only one patient reported a minor adverse event. This specific combination of active ingredients was clinically effective and safe, and contributed to skin surface hydrolipidic film regeneration, improvement of wrinkle depth and reduction of redness.
Highlights
Maintenance of a barrier between the body and the external environment is one of the main functions of the skin
We assessed the efficacy and safety of four skin care products indicated for skin hydration (Aqua Therapy and Perfecta ), skin aging (Unica Resurfacing Therapy ) and sensitive skin (Comfort Therapy ), in four groups of 7 volunteers with different skin types
A single-centre, clinical-instrumental observational prospective study was performed at the Department of Dermatology, University of L’Aquila, Italy, from November 2015 to February 2016, to evaluate the efficacy and safety of four skin care products for skin hydration (Aqua Therapy and Perfecta ), skin aging
Summary
Maintenance of a barrier between the body and the external environment is one of the main functions of the skin. The lipid matrix of the hydrolipidic film is crucial to this, preventing excessive water and electrolyte loss, avoiding penetration of antigenic compounds from the external environment into the epidermal and dermal layers, and facilitating the transfer of antioxidants (e.g. vitamin E) to the surface of the skin [1] [2] [3]. Individual skin type is determined by sebum secretion balance, hydration levels and the re-epithelialization to desquamation ratio. The ratio may be compromised since re-epithelialization is slow, and the natural renewal process can be accelerated by “peeling” the top layer of the skin (resurfacing) [5] [6] Different parameters such as transepidermal water loss, sebum production, elasticity and pH can be used to assess individual skin type [7]. Predominant normal pH of the skin ranges from 4.2 to 5.6 (depending on the specific area of the body), which is slightly acid, and is influenced by the composition of the hydrolipidic film of the stratum corneum [12]
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