Improving Screening for Vascular Cognitive Impairment at 3–6 Months after Ischemic Stroke

Abstract

Event Abstract Back to Event Improving Screening for Vascular Cognitive Impairment at 3–6 Months after Ischemic Stroke Catherine Yanhong Dong1* and Melissa J. Slavin1 1 UNSW Medicine, the University of New South Wales, Psychiatry, Australia Background: A sensitive screening instrument for Vascular Cognitive Impairment (VCI) at the early convalescent phase of stroke, i.e., 3–6 months after stroke, needs to be established. We compared the MoCA and MMSE, with and without the addition of a brief processing speed test, the symbol digit modalities test (SDMT), for VCI screening. Methods: Patients with ischemic stroke and transient ischemic attack were assessed with MoCA, MMSE and a formal neuropsychological battery 3–6 months after stroke. VCI was defined by impairment in any cognitive domain on neuropsychological testing. Area under the receiver operating characteristic curve (AUC) was used to compare test discriminatory ability. Results: 189 of 327 patients (58%) had VCI, of whom the majority, 180 (95%), had vascular Mild Cognitive Impairment (VaMCI) and 9 (5%) had dementia. The overall AUCs of MoCA and MMSE scores and performance at their respective cutoff points were equivalent in detecting VCI (AUCs: 0.87 [95% CI 0.83–0.91] vs. 0.84 [95% CI 0.80–0.88], p = 0.13; Cutoffs: MoCA (≤23) vs. MMSE (≤26), sensitivity: 0.78 vs. 0.71; specificity: 0.80 vs. 0.82; positive predictive value: 0.84 vs. 0.84; negative predictive value: 0.72 vs. 0.67; correctly classified 78.6% vs. 75.5%; p = 0.42).The AUCs of MMSE and MoCA were improved significantly by the SDMT (AUCs: MMSE+SDMT 0.90 [95% CI 0.87–0.93], p Keywords: MMSE, MOCA, Symbol Digit Modalities Test, vascular cognitive impairment, Mild Cognitive Impairment, Stroke, Cognitive screening Conference: ACNS-2013 Australasian Cognitive Neuroscience Society Conference, Clayton, Melbourne, Australia, 28 Nov - 1 Dec, 2013. Presentation Type: Poster Topic: Other Citation: Dong C and Slavin MJ (2013). Improving Screening for Vascular Cognitive Impairment at 3–6 Months after Ischemic Stroke. Conference Abstract: ACNS-2013 Australasian Cognitive Neuroscience Society Conference. doi: 10.3389/conf.fnhum.2013.212.00051 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Oct 2013; Published Online: 25 Nov 2013. * Correspondence: Ms. Catherine Yanhong Dong, UNSW Medicine, the University of New South Wales, Psychiatry, Sydney, Australia, cathdong03@yahoo.com.sg Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Catherine Yanhong Dong Melissa J Slavin Google Catherine Yanhong Dong Melissa J Slavin Google Scholar Catherine Yanhong Dong Melissa J Slavin PubMed Catherine Yanhong Dong Melissa J Slavin Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.