Improving passive transfer of immunoglobulins in calves. I: Dose effect of feeding a commercial colostrum replacer

Abstract

The objective of this study was to describe the effects of feeding 1 or 2 doses of a commercially available colostrum-derived colostrum replacer (CR) on passive transfer of immunoglobulins (Ig) in newborn dairy calves, including IgG, IgG1, IgG2, IgA, and IgM. Newborn calves were removed from the dam before suckling and randomly assigned to 1 of 3 treatment groups: group 1 were fed 1 package (100g of IgG) of CR product, group 2 was fed 2 packages (200g of IgG) of the same CR product, and group 3 was fed 3.8L of maternal colostrum. All colostrum treatments were fed using an esophageal tube feeder within 2h of birth. Blood samples collected before colostrum feeding and at 24h of age were tested for serum total protein and Ig concentrations. Mean 24-h serum total protein (TP) and IgG concentrations were significantly lower for calves in group 1 (n = 24; TP = 4.9 g/dL, IgG = 9.6mg/mL) compared with calves in groups 2 or 3. There was no difference in 24-h serum TP or IgG concentrations between calves in group 2 (n = 23; TP = 5.5 g/dL, IgG = 19.0mg/mL) and calves in group 3 (n = 22; TP = 5.7 g/dL, IgG = 20.7mg/mL). Fifty-four, 100, and 91% of calves in groups 1, 2 and 3 achieved acceptable passive transfer (24-h serum IgG ≥10mg/mL), respectively. Statistically significant but numerically small differences existed between calves in groups 2 and 3 for some 24-h serum Ig classes and subclasses (mean serum concentrations of IgG2, IgA, IgM) and for the relative percentages of Ig classes and subclasses (IgA, IgM, and IgG as a percentage of total Ig; IgG1 and IgG2 as a percentage of total IgG).