Abstract
Early diagnosis and radical surgical excision of oral squamous cell carcinomas are essential for achieving optimal treatment outcomes. To date, diagnostic tools that rely on anatomical anomalies provide limited information and resolution in clinical practice. As a result, oral cancer is often detected in an advanced stage. Also, no reliable real‐time intraoperative tools are readily available for the evaluation of surgical resection margins. Fluorescence imaging visualises biological processes that occur in early carcinogenesis and could, therefore, enable detection of small tumours in early stages. Furthermore, due to the high sensitivity and spatial resolution, fluorescence imaging could assist in resection margin assessment during surgery. In this review, we discuss several techniques that employ fluorescence for early diagnosis and surgical guidance in oral squamous cell carcinoma and present future perspectives on the potential of fluorescence imaging in oral cancer in the near future.
Highlights
Diagnosis and complete tumour resection are considered to be the main pillars of oral squamous cell carcinoma (OSCC) treatment (Mitchell et al, 2018; Wong et al, 2012; Woolgar & Triantafyllou, 2005)
We focus on the current available wide-field fluorescence imaging (FI) techniques that can assist in OSCC diagnosis or surgery
We advocate the use of wide-field FI to highlight suspect areas together with complementary high-resolution imaging techniques to assess particular areas in more detail, such as spectroscopy-based techniques or high-resolution microscopy (Glaser et al, 2017), which fall outside the scope of the current review
Summary
Improving Oral Cavity Cancer Diagnosis and Treatment With Fluorescence Molecular Imaging Voskuil, Floris; Vonk, Jasper; Wit, de, Jaron; Witjes, Max. IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Improving Oral Cavity Cancer Diagnosis and Treatment With Fluorescence Molecular Imaging. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverneamendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. | | Received: 27 November 2019 Revised: 13 February 2020 Accepted: 13 February 2020
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