Abstract
Can memory be improved? In vivo experiments using pharmacological inhibition of the enzyme protein kinase Mζ (PKMζ) in the insular cortex have shown that long-term conditioned taste aversion memory can be blocked. Now, Shema et al. (p. [1207][1]) show that overexpression of PKMζ in the rat insular cortex enhances memory, including memory that was formed long before the enzyme was overexpressed. The enhancement appears to affect more than a single memory. Thus, modulation of PKMζ can alter memories, even months after the initial encoding. [1]: /lookup/doi/10.1126/science.1200215
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