Abstract
Nonenzymatic biosensors do not require enzyme immobilization nor face degradation problem. Hence, nonenzymatic biosensors have recently attracted growing attention due to the stability and reproducibility. Here, a comparative study was conducted to quantitatively evaluate the glucose sensing of pure/oxidized Ni, Co, and their bimetal nanostructures grown on electrospun carbon nanofibers (ECNFs) to provide a low-cost free-standing electrode. The prepared nanostructures exhibited sensitivity (from 66.28 to 610.6 μA mM-1cm-2), linear range of 2-10mM, limit of detection in the range of 1mM, and the response time (< 5s), besides outstanding selectivity and applicability for glucose detection in the human serum. Moreover, the oxidizable interfering species, such as ascorbic acid (AA), uric acid (UA), and dopamine (DA), did not cause interference. Co-C and Ni-C phase diagrams, solid-state diffusion phenomena, and rearrangement of dissolved C atoms after migration from metal particles were discussed. This study undoubtedly provides new prospects on the nonenzymatic biosensing performance of mono-metal, bimetal, and oxide compounds of Ni and Co elements, which could be quite helpful for the fabrication of biomolecules detecting devices.
Highlights
Electrochemical biosensors are a major group of biosensors including considerable applications due to their high sensitivity, ease of construction, and low cost [1,2]
At high temperatures, metal N.P.s diffused from bulk of electrospun carbon nanofibers (ECNFs) to the surface due to the existence of metal concentration gradient between the bulk and ECNFs surface [28,29]
Metal N.P.s were uniformly dispersed on the surface of the ECNF with a narrow size distribution
Summary
Electrochemical biosensors are a major group of biosensors including considerable applications due to their high sensitivity, ease of construction, and low cost [1,2]. Carbon nanofibers as one-dimensional carbon nanomaterials and carbonnanofibers-based nanocomposites have recently been used in supercapacitors [10], fuel cells [11], catalyst protectors [12], and gas sensors [13]. Since they can be employed simultaneously both as a transducer which relays the electrochemical signal and as a highly porous matrix for further loading of nanoparticles. The surfaces of noble metals are quickly fouling by adsorbed interfering intermediates, and chlorine ions in blood This causes interference in the sensitivity and performance of biosensors [23]. The influence of catalyst content and carbonization time (Tc) parameters on the performances of manufactured biosensors electrode was evaluated
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