Improving Natural Resistance to Cancer: An Overview of Metabolic Pathways in Cancer Cells Integrated with Regional Cancer Incidence Statistics

Abstract

Context: Cellular metabolism is a set of controlled biochemical reactions known as metabolic pathways that occur in living organisms in order to sustain life. Cells may use different metabolic pathways and alter metabolism to use more effective processes for survival depending on cellular conditions. Alterations in metabolic pathways can lead to the transformation of normal cells into cancerous cells, leading to cancer initiation and development. Objectives: Proper cellular conditions in terms of pH and the availability of essential nutrients and oxygen are important for the healthy functioning of aerobically respiring human cells. If cells are exposed to stressors such as carcinogens that can induce mutations in the genes involved in metabolic pathways, anaerobic metabolism may be used by cells, turning them into cancerous cells. Cellular conditions that maintain aerobic cellular respiration and mitigate the effects of cellular stressors can improve cells’ resistance to neoplastic transformation. Methods: This paper explores the key metabolic pathways used by cancer cells as a function of their environmental conditions based on the Warburg effect. In addition, some analyses and studies were conducted on global and regional cancer incidence rates, taking into account changes in lifestyle and dietary patterns. Results and Conclusions: Natural resistance to cancer may be improved when cells grow in healthy conditions at molecular levels, requiring a balanced alkalizing diet and healthy lifestyle, as well as reduced exposure to environmental carcinogens, which are key control factors. In particular, effective nutritional interventions can help normal cells resist metabolic changes underlying cancer development.