Abstract
This study aimed to explore the effect of combined psychological and nutritional interventions on anxiety, depression, nutritional status, and quality of life among liver cancer patients implanted with iodine-125 seeds under the PERMA model. A total of 82 liver cancer patients admitted to our hospital were randomly allocated into two groups: a control group receiving routine care and an observation group receiving the aforementioned combined intervention under the PERMA model. The study duration spanned three months, after which the Hospital Anxiety and Depression Scale, Mini Nutritional Assessment-Short Form, and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire scores were compared between the groups. Post-intervention findings revealed that the observation group exhibited significantly higher scores in hospital anxiety and depression assessments compared to the control group. Additionally, the observation group demonstrated a significantly higher proportion of patients with good nutritional status, as per the Mini Nutritional Assessment-Short Form. Furthermore, improvements were observed across all dimensions of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, with the observation group showing significantly higher scores in comparison to the control group. These findings highlight the substantial value of integrating psychological intervention with nutritional support within the PERMA model as a means to enhance clinical nursing practices.
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