Abstract

Background HIV-1 envelope (Env) gp120 is an important target for neutralizing antibody (Ab) responses against the virus. However, developing gp120 vaccines that elicit potent and broad neutralizing Abs has proven to be a formidable challenge. The envelope gp120 is highly glycosylated and carbohydrate moieties play an important role in modulation of immunobiological property of HIV-1 Env gp120. Previously, removal of a specific N-linked glycan at residue 448 by N to Q mutation (N448Q) has been found to enhance in vitro antigenicity of neutralizing epitopes in the V3 loop. In the present study we examined immunogenicity of mutant gp120 in mice.

Highlights

  • HIV-1 envelope (Env) gp120 is an important target for neutralizing antibody (Ab) responses against the virus

  • In the present study we examined immunogenicity of mutant gp120 in mice

  • Neutralizing activity was directed to V3 and other undefined neutralizing epitopes

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Summary

Background

HIV-1 envelope (Env) gp120 is an important target for neutralizing antibody (Ab) responses against the virus. Developing gp120 vaccines that elicit potent and broad neutralizing Abs has proven to be a formidable challenge. The envelope gp120 is highly glycosylated and carbohydrate moieties play an important role in modulation of immunobiological property of HIV-1 Env gp120. Removal of a specific N-linked glycan at residue 448 by N to Q mutation (N448Q) has been found to enhance in vitro antigenicity of neutralizing epitopes in the V3 loop. In the present study we examined immunogenicity of mutant gp120 in mice

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Results
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