Abstract
Improving GHB withdrawal with baclofen
Highlights
Our clinical experience was that in to addition to benzodiazepines, baclofen, which is a medication that targets the same system in the brain as GHB, the GABA-B system, may be beneficial in improving GHB detoxification and that starting baclofen 2 days prior to stopping GHB may help further
Dependence on GHB is associated with withdrawal symptoms that are similar to alcohol withdrawal but generally more severe
This feasibility study did not achieve its projected rate of recruitment currently less people are presenting with GHB dependence for detox
Summary
We are cautious in drawing any conclusions due to small participant numbers it was evident that participants welcomed the opportunity to take part in the trial due to expertise of study team, that there is limited expertise outside specialist centres to access, and that service reconfigurations and changes in GHB use contributed to the challenge of recruiting and conducting the study. We advise that outpatient GHB detoxification is a challenging clinical situation to manage and expert advice and inpatient facilities must be available. Keywords Baclofen Gamma-Hydroxybutyrate (GHB) Withdrawal Dependence Detoxification
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