Improving estimation efficiency for semi-competing risks data with partially observed terminal event

Abstract

ABSTRACTSemi-competing risks data arise when two types of events, non-terminal and terminal, may be observed. When the terminal event occurs first, it censors the non-terminal event. Otherwise the terminal event is observable after the occurrence of the non-terminal event. In practice, it can be hard to ascertain all terminal event information after the non-terminal event. Yu and Yiannoutsos [(2015), ‘Marginal and Conditional Distribution Estimation from Double-Sampled Semi-Competing Risks Data’, Scandinavian Journal of Statistics, 42, 87–103] considered a setting when the terminal event is ascertained via double sampling from only a subset of patients who experienced the non-terminal event. They discussed estimation for marginal and conditional distributions under this double sampled semi-competing risk data framework. We propose a more efficient estimation method in the same setting by fully utilising the non-terminal event information. The efficiency gain can be substantial as observed in our simulation study.