Abstract
Abstract Multicomponent interference in ion-exchange chromatography is examined in this paper. A multicomponent chromatography theory is used to analyze the effect of eluent affinity in elution chromatography, and displacer and presaturant affinity in displacement chromatography. The eluent should have an affinity between those of the feed components and near the strongest affinity species. In displacement chromatography, the displacer and presaturant affinities should bracket those of the desired products as closely as possible. Displacement chromatography produces pure product peaks, although the feed throughput is larger for elution chromatography. These conclusions are also valid for adsorption chromatography.
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