Abstract
Improving Drug Uptake and Penetration into Tumors: Current and Forthcoming Opportunities
Highlights
The main scope of this topic is to give an update on approaches being studied and developed to improve tumor drug delivery through active targeting and other methods
It is causally related to the abnormal tumor architecture
Poor vascularization, increased resistance to blood flow and impaired blood supply represent a first obstacle to the delivery of antitumor drugs to tumor cells
Summary
The main scope of this topic is to give an update on approaches being studied and developed to improve tumor drug delivery through active targeting and other methods. Inadequate drug accumulation has emerged as one of the main problems underlying therapeutic failure and drug resistance in the treatment of solid tumors (Trédan et al, 2007; Marcucci and Corti, 2012a). Poor vascularization, increased resistance to blood flow and impaired blood supply represent a first obstacle to the delivery of antitumor drugs to tumor cells.
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