Abstract
Cancer Detection In article number 2100081, I-Wei Chen, Rong Zhou, and co-workers demonstrate that a peptide-based nanodelivery platform made of pH-sensitive peptides (blue, turning red when protonated in low pH) and decorated by PEG (yellow) can be used to formulate poorly water-soluble small molecules to improve cancer diagnosis and treatment. The pH-sensitive nanoparticles, stable in blood, self-dissolve in a mildly acidic extracellular space of the tumor, thereby releasing encapsulated molecular drug cargos (silver spheres) near tumor cells.
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