Abstract
A novel nanofibrous coating containing chitosan and mineralized bone allograft (MBA) nanoparticles was fabricated on AZ31 magnesium alloy via electrospinning in order to enhance corrosion and biocompatibility behavior in a physiological environment. A number of specimens were initially anodized to assess its effect on the improvement of the adhesion between the electrospun nanofibrous coating and the substrate. The coated materials were characterized by using SEM, EDS, FT-IR, and TG. Wettability and the adhesion of the coatings were also studied. In addition, hydrogen evolution and corrosion resistance were evaluated by conducting the immersion test, electrochemical polarization, and EIS tests, respectively. The results showed that both chitosan and chitosan/ MBA composite nanocoating improved the corrosion resistance. Cytotoxicity examination using fibroblast cells indicated that the presence of MBA nanoparticles in chitosan nanofibrous coating has preferable cell adhesion and proliferation. On the whole, application of both chitosan and chitosan/ MBA nanoparticles composite nanofibrous coatings on pre-anodized magnesium appears to be a promising approach in enhancement of the corrosion and biological behavior of magnesium-based biomaterials.
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