Abstract
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN are finding use as vaccine adjuvants based on their ability to increase the speed, magnitude and duration of vaccine-specific immune responses. We conducted studies examining the capacity of CpG ODN to accelerate and prolong the protection induced by AVA (Anthrax Vaccine Adsorbed). Co-administering CpG-adjuvanted AVA with Dalbavancin, a long-activity antibiotic, protected naive mice from both the immediate and long-term threat posed by exposure to anthrax spores. A majority of animals immunized only once with CpG-adjuvanted AVA maintained resistance to anthrax infection for more than one year, even after their Ab titers declined to sub-protective levels. This survival was mediated by the de novo production of protective Abs by high affinity long-lived memory B cells that were generated by vaccination with CpG-adjuvanted AVA.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
