Improvements in Airway Hyperresponsiveness and Inflammation in an Asthma Model via Upregulation of Anti-Oxidant Responses with 2-Cyano-3,12-Dioxooleana-1,9 (11)-Diene-28-Oic Acid Trifluoroethyl Amide (CDDO-TFEA)

E.G Brooks,D Nanyez,S Shulz,C Meyer,M.B Sporn,D.J Hochman

doi:10.1016/j.jaci.2007.12.1012

Improvements in Airway Hyperresponsiveness and Inflammation in an Asthma Model via Upregulation of Anti-Oxidant Responses with 2-Cyano-3,12-Dioxooleana-1,9 (11)-Diene-28-Oic Acid Trifluoroethyl Amide (CDDO-TFEA)

E.G Brooks, D Nanyez + Show 4 more

Open Access

https://doi.org/10.1016/j.jaci.2007.12.1012

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Journal: Journal of Allergy and Clinical Immunology

Publication Date: Feb 1, 2008

Affiliation: The University of Texas Medical Branch at Galveston, Reata Pharmaceuticals (United States)

#Airway Hyperresponsiveness #Upregulation Of Anti-Oxidant Responses + Show 8 more

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Abstract

Elevated levels of reactive oxygen species (ROS) induce cellular injury and promote airway inflammation and hyperresponsiveness (AHR) in animal models of asthma. CDDO-TFEA, a compound that upregulates transcriptional anti-oxidant response elements (ARE) through the Nrf2 pathway, may be useful in protecting against oxidative injury in asthma.

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