Abstract
Heart diseases affect part of world population and generally involves the functioning of valves. Valves replacement is the most common treatment and the choice between synthetic or natural/biological implants depends on several factors. Synthetic implants have greater durability, whereas biological ones are more biocompatible. This work proposes the use of polymeric coating on titanium metal surface to increase implant biocompatibility. Poly-caprolactone (PCL) has demonstrated greater efficacy for biomedical applications due to its biocompatibility. It can easily form films and coat surfaces. Titanium discs were submitted to alkaline and thermal treatments and coated with 1%PCL and 1%PCL+TiO2. For both conditions, PCL crystals were found in titanium coated surface (SEM and EDX) and X-ray diffractogram confirmed PCL coating. Infrared Spectroscopy spectra showed both PCL and TiO2 characteristic peaks. Moreover, corrosion resistance of coated disc has considerably increased, proving the effectiveness of PCL as coating material and its potential application in cardiac valves.
Highlights
Heart diseases affect a large part of the world population
The key of mechanical valves are their durability[3].The main materials used in the manufacture of mechanical valves, such as those produced by BjorkShiley, LilleheiKaster, Omniscience, MedtronicHall or St.Judes, are pyrolytic carbon and titanium
Titanium discs were submitted to alkaline and thermal treatments in order to clean the surface and improve coatings adhesion[16,17]
Summary
Heart diseases affect a large part of the world population. In Brazil, they were the second cause of death. The key of mechanical valves are their durability[3].The main materials used in the manufacture of mechanical valves, such as those produced by BjorkShiley, LilleheiKaster, Omniscience, MedtronicHall or St.Judes, are pyrolytic carbon and titanium. A patient who has been implanted with a mechanical valve needs to be take anticoagulant medicine to prevent heart attack and stroke[4]. To eliminate this lifelong medication need after heart valve replacement, numerous studies have been developed in order to reduce the thrombogenicity of substitute valves . To eliminate this lifelong medication need after heart valve replacement, numerous studies have been developed in order to reduce the thrombogenicity of substitute valves . 5,6,7,8
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