Abstract
The purpose of this study is to investigate the bioavailability and glycaemic metabolism of cinnamon oil (CIO) carried by liquid-loadable tablets (CIO-LLTs), the carrier of a CIO self-emulsifying formulation (CIO-LS). The results of tests performed to evaluate the physical properties of the CIO-LLT complied with Chinese Pharmacopeia (2010). The release profile suggested that the CIO-LLT preserved the enhancement of in vitro dissolution of cio. After orally administration, the plasma concentration-time profile and pharmacokinetic parameters suggested that a significant increase (P < 0.0001) in the C max, AUC and F were observed in the CIO-LLT. The blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic rats (P < 0.05, P < 0.01, resp.), while the level of insulin secretion was markedly elevated in alloxan-induced hyperglycemic rats (P < 0.05). The alloxan-damaged pancreatic β-cells of the rats were partly recovered gradually after the rats were administered with CIO-LLT 45 days later. CIO-LLT could improve the bioavailability and glycaemic metabolism of CIO.
Highlights
According to the World Health Organization, it is estimated that approximately 150 million people worldwide have diabetes mellitus at present [1]
The work presented in this paper focuses on the pharmacokinetic (PK) performance of cinnamon oil (CIO) from loaded LLT and the effects of CIO-loadable tablets (CIO-LLT) on glycaemic metabolism
The work presented in this paper focuses on the ability of LLT prepared from Magnesium aluminometasilicate (MAS) to be loaded with a selfemulsifying drug delivery systems (SEDDSs) system containing CIO, the pharmacokinetic (PK) performance of CIO from loaded LLT and the effects of CIO-loadable tablets (CIO-LLT) on glycaemic metabolism
Summary
According to the World Health Organization, it is estimated that approximately 150 million people worldwide have diabetes mellitus at present [1]. New therapeutic approaches are needed to treat diabetes more efficiently. There is growing interest in herbal remedies due to the side effects associated with the oral hypoglycemic agents for the treatment of diabetes mellitus [2]. The plant kingdom is a wide field to search for natural effective oral hypoglycemic or hypolipidemic agent that has slight or no side effects. More than 400 plants with glucose lowering effect are known [3]. They might be used in various forms like food and medicines, which contain both organic and inorganic constituents
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