Abstract
The method of determining the longitudinal relaxation time of hyperpolarized 129Xe in the mouse brain has been established in vivo with the ventilation technique under controlled-flow conditions. The uptake and washout processes for nine mice were traced through observation of time-dependent changes in NMR (nuclear magnetic resonance) signal amplitudes and analyzed by means of a two-compartment model, thus providing the quantitative value of 14.1+/-1.6 s as the relaxation time.
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